Table of early side effects of common medicines for depression

Symbols:

  –   Very few people report this symptom

  +   Less than 1 out of 10 people report this symptom

  ++   1 to 3 out of 10 people report this symptom

  +++  3 to 5 out of 10 people report this symptom

  ++++  5 out of 10 or more people report this symptom

Note:

SSRI= selective serotonin reuptake inhibitors

SNRI= selective norepinephrine serotonin reuptake inhibitors.

 

Medication Side Effect
Nausea Diarrhea Constipation Dry Mouth Sweating
SSRI Group
citalopram (Celexa) + + + + + + +
escitalopram (Ciprolex) + + + + + +
fluoxetine (Prozac) + + + + +
fluvoxamine (Luvox) + + + + + + + + + +
paroxetine (Paxil) + + + + + + + + + +
sertraline (Zoloft) + + + + + + + + +
SNRI Group
venlafaxine (Effexor) + + + + + + + + + +
desvenlafaxine (Pristiq) + + + + + + + + +
duloxetine (Cymbalta) + + + + + + + + +
Other antidepressants
bupropion (Wellbutrin) + + + + + + +
mirtazapine (Remeron) + + + +

Other common early side effects of antidepressant medications

Medication Side Effect
Daytime sleepiness Trouble sleeping Headache Shakiness Dizziness
SSRI Group
citalopram (Celexa) + + +
escitalopram (Ciprolex) + + + +
fluoxetine (Prozac) + + + + + +
fluvoxamine (Luvox) + + + + + + + + + + + +
paroxetine (Paxil) + + + + + + + + +
sertraline (Zoloft) + + + + + + + + + + +
SNRI Group
venlafaxine (Effexor) + + + + + + + + +
desvenlafaxine (Pristiq) + + + + + + + +
duloxetine (Cymbalta) + + + + + +
Other antidepressants
bupropion (Wellbutrin) + + + +
mirtazapine (Remeron) + + + + + +

Note:

Tables adapted from RW Lam, SH Kennedy, S Grigoriadis, RS McIntyre, R Milev, R Ramasubbu, SV Parikh, SB Patten, AV avindran. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy, Journal of Affective Disorders 117 (2009) S26–S43. SSRI= selective serotonin reuptake inhibitors, SNRI= selective norepinephrine serotonin reuptake inhibitors.

Please See:

What happens when the medicine is gradually reduced and eventually stopped?

How long should you keep taking the medicine?

How long does it take for the medicine to work?

Side effects

Cost of medication

Combining medication and therapy